Cosmetic Raw Materials Poloxamer 184 188 407 White Powder CAS 9003-11-6

Cosmetic Raw Materials Poloxamer 184 188 Poloxamer 407 CAS 9003-11-6

Description:
Poloxamer is a block copolymer consisting of polyethylene glycol (PEG) and polypropylene glycol (PPG) units. It is available in various grades with different molecular weights and ratios of PEG to PPG segments. The most commonly used grades include Poloxamer 188 (also known as Pluronic F68) and Poloxamer 407 (Pluronic F127).

Specification:

• Chemical Formula: Variable, depending on the specific grade
• Appearance: Clear or slightly turbid liquid, or white waxy solid
• Molecular Weight: Varies depending on the specific grade
• Solubility: Soluble in water and many organic solvents

Application:
Poloxamer finds a wide range of applications, including:

1. Chemical Industry: Poloxamer is extensively used in Chemical formulations. It acts as a solubilizer, emulsifier, and stabilizer in various oral, topical, and parenteral dosage forms. It can improve the solubility of poorly soluble drugs, enhance drug delivery, and modify the rheological properties of formulations. It is commonly found in ophthalmic solutions, creams, gels, and suppositories.

2. Cosmetics and Personal Care Products: Poloxamer is used in cosmetics and personal care products as an emulsifier, dispersant, and stabilizer. It helps to create stable emulsions, improve product texture, and enhance the spreadability of formulations. It is found in creams, lotions, shampoos, and other skincare and haircare products.

3. Industrial Applications: Poloxamer is utilized in various industrial processes. It is used as a lubricant, antistatic agent, and emulsifier in the textile, paper, and plastics industries. It can also be used in cleaning products, metalworking fluids, and as a dispersant in paints and coatings.

Features:

• Nonionic Surfactant: Poloxamer is a nonionic surfactant, meaning it does not carry an electric charge in solution. This property makes it compatible with a wide range of other ingredients and formulations.

• Thermoresponsive Behavior: Some Poloxamer grades, such as Poloxamer 407, exhibit a thermoresponsive behavior. They can undergo a sol-gel transition at higher concentrations, forming a gel at lower temperatures. This property is advantageous in the formulation of certain drug delivery systems and topical gels.

• Biocompatibility: Poloxamer is generally considered biocompatible and non-toxic. It has low irritancy and is well-tolerated by the skin and mucous membranes. However, specific grades and concentrations should be evaluated for safety in each application.

• Solubility: Poloxamer is highly soluble in water and can form clear solutions over a wide range of concentrations. It can also be soluble in various organic solvents, allowing for versatility in formulation.