Poloxamer 188/ Poloxamer 407/ Polyethylene Polypropylene Glycol CAS 9003-11-6

Poloxamer 188/ Poloxamer 407/ Polyethylene Polypropylene Glycol CAS 9003-11-6

Description:
Poloxamer, also known as Pluronic, is a nonionic triblock copolymer composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) units. It is a clear, viscous liquid or solid at room temperature, depending on its specific grade. Poloxamers are designated with a number, such as Poloxamer 188 or Poloxamer 407, which indicates their molecular weight and composition.

Specification:
The specifications of Poloxamer can vary depending on the specific grade and application. Here are some general specifications:

• Chemical formula: Variable, depending on the specific Poloxamer grade
• Molecular weight: Varies depending on the Poloxamer type, typically ranging from 2,000 to 14,000 g/mol
• Appearance: Clear, colorless or slightly yellowish liquid or solid
• Purity: Typically, not less than 99% or higher (depending on the grade)
• Hydroxyl value: Varies depending on the specific Poloxamer grade
• pH: Generally neutral (around 6-8)

Application:
Poloxamer has various applications in different industries, including:

1. Chemical and medical: Poloxamer is widely used in Chemical formulations and medical applications. It is employed as a solubilizer, emulsifier, and stabilizer in liquid and semi-solid dosage forms such as creams, ointments, gels, and suppositories. Poloxamers can improve drug solubility, enhance bioavailability, and provide controlled drug release. They are also utilized in eye drops, nasal sprays, and other topical formulations.

2. Personal care and cosmetics: Poloxamer is utilized in the personal care and cosmetic industry. It is commonly found in skincare products, cleansers, shampoos, and conditioners. Poloxamers act as emulsifiers, surfactants, and texture modifiers, providing stability, foam enhancement, and improved sensory properties.

3. Industrial applications: Poloxamer has industrial applications as well. It is used as a lubricant and dispersant in various industrial processes, including plastics manufacturing, rubber production, and metalworking. Poloxamers can improve flow properties, reduce friction, and aid in dispersion of particles.

Features:

1. Nonionic nature: Poloxamer is a nonionic copolymer, meaning it does not carry an electrical charge. This property makes it compatible with a wide range of ingredients and formulations, as it does not interact strongly with pH or ionic conditions.

2. Thermal reversible gelation: Some Poloxamers exhibit a unique property known as thermal reversible gelation. They can form gels at lower temperatures and revert to a liquid state upon heating. This feature is useful in Chemical formulations and can provide controlled drug release.

3. Solubilizing and emulsifying capabilities: Poloxamers have the ability to solubilize hydrophobic substances and stabilize emulsions. They can help improve the solubility and bioavailability of poorly soluble drugs and enhance the stability of oil-in-water or water-in-oil emulsions.

4. Biocompatibility: Poloxamers are generally considered biocompatible and well-tolerated by the body, making them suitable for Chemical and medical applications. They are commonly used in ophthalmic and intravenous formulations.