CAS 701-54-2 Tranexamic Acid TXA Medicine Grade Reduce Excessive Bleeding

CAS 701-54-2 Tranexamic Acid TXA Medicine Grade Reduce Excessive Bleeding 

Tranexamic Acid - Description

Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine with the chemical formula C8H15NO2. It functions as an antifibrinolytic agent by inhibiting the activation of plasminogen to plasmin, the enzyme responsible for the breakdown of fibrin clots. TXA is widely used in medicine to prevent or reduce excessive bleeding during surgeries, trauma, or medical conditions such as heavy menstrual bleeding. Additionally, it is used in dermatology for its skin-brightening and anti-pigmentation properties.

Technical Data Sheet

Mechanism of Action

Tranexamic acid works by inhibiting plasminogen activation and plasmin activity, preventing the breakdown of fibrin clots. This antifibrinolytic action stabilizes blood clots, reducing bleeding in various medical conditions.

Features

1. Antifibrinolytic Activity:

   • Potent inhibitor of fibrinolysis, effective in reducing excessive bleeding.

2. Skin-Brightening Properties:

   • Inhibits melanin synthesis by blocking the interaction of melanocytes and keratinocytes, reducing hyperpigmentation.

3. High Water Solubility:

   • Easily dissolves in aqueous formulations for medical and dermatological use.

4. Safe and Well-Tolerated:

   • Low side effect profile when used at therapeutic doses.

5. Versatile Applications:

   • Effective in systemic, local, and topical formulations (e.g., oral tablets, injectables, and creams).

Applications

1. Medical Applications

• Hemostasis:
  • Prevents or reduces excessive bleeding in:
    • Trauma patients.
    • Surgeries (e.g., cardiac, orthopedic, dental).
    • Postpartum hemorrhage.
    • Menorrhagia (heavy menstrual bleeding).
• Hereditary Angioedema:
  • Reduces the frequency and severity of attacks.

2. Dermatological Applications

• Hyperpigmentation Treatment:
  • Used in creams, serums, and oral medications to treat:
    • Melasma.
    • Post-inflammatory hyperpigmentation (PIH).
    • Dark spots and uneven skin tone.
• Anti-Aging:
  • Helps brighten and even out skin tone.

3. Pharmaceutical Formulations

• Oral Tablets:
  • Typically for systemic antifibrinolytic therapy.
• Injectable Solutions:
  • Used in emergency and surgical settings.
• Topical Creams and Serums:
  • For cosmetic and dermatological purposes.