CAS 123-99-9 Cosmetic Grade Azelaic Acid For Skin Treatment Of Acne And Melasma

CAS 123-99-9 Cosmetic Grade Azelaic Acid For Skin Treatment Of Acne And Melasma

Azelaic Acid - Description

Azelaic acid is a naturally occurring dicarboxylic acid derived from grains such as wheat, barley, and rye. It has the chemical formula C9H16O4 and is widely used in dermatology and cosmetics due to its antibacterial, anti-inflammatory, keratolytic, and skin-brightening properties. Azelaic acid is particularly effective in treating conditions like acne, rosacea, hyperpigmentation, and melasma. It is also valued for its gentle nature, making it suitable for sensitive skin types.

Technical Data Sheet

Features

1. Antibacterial Properties:

   • Inhibits the growth of skin bacteria such as Propionibacterium acnes and Staphylococcus epidermidis, which are responsible for acne.

2. Anti-Inflammatory:

   • Reduces redness and inflammation, making it effective in treating rosacea and acne.

3. Keratolytic Action:

   • Promotes gentle exfoliation by normalizing skin cell turnover and unclogging pores.

4. Skin-Brightening:

   • Inhibits tyrosinase, an enzyme involved in melanin production, which helps reduce hyperpigmentation, melasma, and dark spots.

5. Non-Comedogenic:

   • Does not block pores, making it suitable for acne-prone skin.

6. Gentle on Skin:

   • Less irritating compared to other actives like benzoyl peroxide or retinoids, ideal for sensitive skin.

7. Safe for Long-Term Use:

   • Well-tolerated with minimal risk of resistance or adverse effects.

Applications

1. Dermatology

Azelaic acid is widely used in prescription and over-the-counter (OTC) treatments for:

• Acne:
  • Reduces bacteria and inflammation while unclogging pores.
• Rosacea:
  • Eases redness and irritation associated with the condition.
• Hyperpigmentation:
  • Treats melasma, post-inflammatory hyperpigmentation (PIH), and uneven skin tone.
• Keratosis Pilaris:
  • Improves skin texture by reducing rough and bumpy skin.

2. Cosmetics and Personal Care

In cosmetic formulations, azelaic acid is found in:

• Skin-Brightening Products:
  • Serums and creams targeting dark spots and uneven skin tone.
• Anti-Acne Products:
  • Gels, creams, and lotions formulated for acne-prone skin.
• Exfoliating Products:
  • Gentle exfoliants that improve skin texture and radiance.
• Sensitive Skin Products:
  • Formulations designed for redness-prone or irritated skin.

3. Pharmaceutical Formulations

• Prescription Medications:
  • Azelaic acid is available in 15% or 20% topical creams or gels for treating acne and rosacea.
• OTC Products:
  • Concentrations of 10% or lower are used in non-prescription skincare products.

Benefits in Skin Care