1H-Indazole-3-carboxylic acid methyl esters ≥98% purity white solid for medicinal chemistry intermediates

Description

1H-Indazole-3-carboxylic acid methyl esters is an organic heterocycle derivative of indazole featuring a methyl esters at the 3-carboxylate position. It is commonly used as an intermediate in the synthesis of medicinal chemistry targets (e.g., kinase inhibitors, anti-inflammatory/analgesic scaffolds, and other indazole-based bioactive molecules).

Specifications 

Features

• Indazole scaffold: heteroaromatic core frequently used in kinase and CNS-related medicinal chemistry.
• Ester functional group: methyl esters provides reactivity/selectivity for downstream transformations (e.g., hydrolysis to acid, amidation, transesterification).
• Synthesis intermediate: often used as a building block to access 1H-indazole-3-carboxylic acid derivatives and further substituted analogs.
• Bench-stable solid : convenient handling compared with some more reactive acid derivatives.

Applications

1. Medicinal chemistry intermediate
   • Synthesis of indazole-based inhibitors and bioactive compounds.
2. Preparation of carboxylic acid derivatives
   • Hydrolysis to 1H-indazole-3-carboxylic acid, then coupling to amides/peptides.
3. Ester-to-amides/ester transformations
   • Formation of substituted carboxamide libraries for SAR (structure–activity relationship) studies.
4. Chemical building block
   • Used to introduce the indazole-3-carboxylate fragment into target molecules.

Storage

• Store in a tightly closed container.
• Protect from:
  • Moisture/humidity
  • Light (store in amber container or keep away from light if recommended)
  • Heat
• Use in a dry environment to minimize hydrolysis.

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