CAS 60-01-5 Dietary Supplement Tributyrin (Glyceryl Tributyrate) For Human And Animal Nutrition

Description

Tributyrin (Glyceryl tributyrate) is a triglyceride ester derived from glycerol and three butyric acid molecules. It is a clear, colorless to pale yellow, oily liquid with a characteristic odor. In nature, it is a minor component of butter. Its primary value lies in its role as a stable, tasteless precursor to butyric acid, a short-chain fatty acid (SCFA) with critical physiological functions in gut health, metabolism, and cellular regulation. Upon ingestion, enzymes (lipases) in the digestive tract hydrolyze Tributyrin to release butyric acid directly at the site of action.

Specification  

Key Features & Benefits

• Targeted Release of Butyrate: Acts as a prodrug, delivering butyric acid directly in the intestines where it is needed, avoiding unpleasant taste and gastric side effects.
• High Purity & Stability: More stable and easier to handle than free butyric acid (which is volatile and has a strong rancid odor).
• Efficient Absorption: As a triglyceride, it utilizes natural fat digestion pathways for efficient uptake and hydrolysis.
• Versatile Application Forms: Suitable for use in oil-based liquids, softgels, powder formulations (via encapsulation), and coated tablets.
• Generally Recognized as Safe (GRAS): Approved for use as a food additive and dietary ingredient in many regions.

Applications

1. Human & Animal Nutrition / Dietary Supplements:

• Gut Health: Supports the integrity of the intestinal lining, reduces inflammation, and serves as the primary energy source for colonocytes (colon cells). Used for conditions like leaky gut, IBS, and IBD support.
• Metabolic Health: Influences insulin sensitivity, energy metabolism, and has been studied for its role in weight management.
• Epigenetic Regulation: Butyrate is a histone deacetylase (HDAC) inhibitor, influencing gene expression related to cell proliferation, apoptosis, and inflammation.

2. Animal Feed Additive (especially poultry, swine, aquaculture):

• Growth Promoter & Alternative to Antibiotics: Enhances gut health, improves feed efficiency, boosts immunity, and increases growth performance.
• Intestinal Pathogen Control: Creates an unfavorable environment for harmful bacteria like Salmonella and E. coli.

3. Pharmaceutical & Medical Research:

• Investigated for its potential anti-cancer (particularly colorectal cancer), anti-inflammatory, and neuroprotective properties.
• Used as a component in medical delivery systems.

4. Industrial & Laboratory Uses:

• Plasticizer: For cellulose esters and other polymers.
• Flavor & Fragrance Ingredient: In minute quantities for buttery notes.
• Biochemical Research: As a substrate for lipase activity assays.

Packing & Storage